Siblings with Concordant Gender Dysphoria and Divergent Upbringing Environments: Case Report and Literature Review of Neurobiological Identity Factors

Case Report | Open Access

Volume 2026 - 4 | Article ID 263 | http://dx.doi.org/10.51521/AJCRCI.2026.e42.164

Siblings with Concordant Gender Dysphoria and Divergent Upbringing Environments: Case Report and Literature Review of Neurobiological Identity Factors

Academic Editor: John Bose

Received 2026-09-09
Revised 2026-10-03
Accepted 2026-10-01
Published 2026-10-05

Jose Luis Rojas-Oviedo¹, María Fernanda Leal Walteros¹, Diana Carolina Vargas Fiesco², Dauris Lineth Mejía Pérez³, Wilmer Alexander Hernández Lizarazo⁴, Juan Carlos Vallejo-Soto⁵

¹Second Year Obstetrics and Gynecology Resident, Universidad Nacional de Colombia, Bogotá, Colombia.

²Obstetrics and Gynecology Specialist, Reproductive Medicine Fellow, Gender Clinic Endocrinologist, Subred Integrada de Servicios de Salud Norte, Assistant Professor, Universidad Nacional de Colombia, Bogotá, Colombia.

³Obstetrics and Gynecology Specialist, Subred Integrada de Servicios de Salud Norte, Máster in Public Health, Assistant Professor, Universidad Nacional de Colombia, Bogotá, Colombia.

⁴Obstetrics and Gynecology Specialist, Universidad del Rosario, Master in Superior Education in Health, Universidad de Antioquia, Associated Professor, Unisanitas.

⁵Máster in Epidemiology, Universidad del Rosario.

Corresponding author: Jose Luis Rojas-Oviedo, Universidad Nacional de Colombia, Email: jrojasov@unal.edu.co; ORCID: 0000-0001-8802-3095

Citation: Jose Luis Rojas-Oviedo, María Fernanda Leal Walteros, Diana Carolina Vargas Fiesco, Dauris Lineth Mejía Pérez, Wilmer Alexander Hernández Lizarazo, Juan Carlos Vallejo-Soto, (2026). Siblings with Concordant Gender Dysphoria and Divergent Upbringing Environments: Case Report and Literature Review of Neurobiological Identity Factors. American J Case Rep Clin Imag. 2026; October, 4(2), 1-3.

Copyrights © 2026, Jose Luis Rojas-Oviedo, et al, This article is licensed under the Creative Commons Attribution-Non-Commercial-4.0-International-License-(CCBY-NC) (https://amejcaserepclinimag.com/blogpage/copyright-policy). Usage and distribution for commercial purposes require written permission.

Abstract:

Two assigned females at birth siblings separated neonatally and raised in disparate environments independently developed early-onset gender dysphoria, affirming male identities in adulthood. These shared trajectories, despite significant environmental variance, support a durable biological foundation for gender identity. Results highlight the resilience of innate factors in determining gender development.

Keywords: Gender Dysphoria, Transgender, Genetics, Neurobiology, Environment.