Hafsa Khalid, A. Mastrosimone

Corresponding Author: Hafsa Khalid, Department of General and Upper Gastrointestinal Surgery, Connolly Hospital Blanchardstown, Dublin, Ireland, ORCID: https://orcid.org/0009-0004-6825-5218

Citation: Hafsa Khalid, A. Mastrosimone (2026 Endosalpingiosis in a Young Woman: A Rare Cause of Chronic Abdominal Pain – Case Report and Comprehensive Literature Review. American J Case Rep Clin Imag. 2026; May, 4(1),1-6.

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ABSTRACT

Background: Endosalpingiosis is a rare, benign gynecological condition characterized by ectopic ciliated tubal-type epithelium located outside the fallopian tubes. While typically an incidental finding during gynecological procedures, symptomatic presentations remain exceptionally uncommon, particularly in younger women. A systematic review spanning the past decade identified only 15 documented cases, with 93% occurring in postmenopausal women aged 50 years and above [1].

Case Presentation: We present an atypical case of symptomatic endosalpingiosis in a woman in her early twenties presenting with chronic right-sided abdominal pain exacerbated by menstruation. Diagnostic laparoscopy, performed to evaluate persistent symptoms and an incidental appendicolith finding, revealed a small peritoneal nodule that was histologically and immunohistochemically confirmed as endosalpingiosis.

Outcome: Following surgical excision and initiation of hormonal therapy with oral contraceptives, the patient achieved complete symptom resolution and remained asymptomatic at 6-month follow-up.

Clinical Significance: This case highlights the importance of recognizing endosalpingiosis as a potential differential diagnosis in young women with unexplained chronic abdominal pain, particularly when conventional diagnostic workup remains unrevealing. We discuss the pathophysiological mechanisms, diagnostic challenges, treatment strategies, and significant research gaps in the current literature.

Keywords: endosalpingiosis, chronic abdominal pain, Müllerian remnants, diagnostic laparoscopy, benign gynecological conditions.